"Bio-Ost" MATRIX
"Bio-Ost" MATRIX
Natural bone substitute with a bimodal porous structure with different fragmentation and different behavior to solve any clinical problem

It is used in traumatology and orthopedics to fill in bone defects, treat of delayed consolidation, false joints and other reconstructive operations. The "Bio-Ost" matrix is a purified sterile bone tissue of young cattle that has passed strict veterinary control. Depending on the residual content of the inorganic phase, the osteoplastic matrix is produced demineralized (with a reduced mineral content) and non-demineralized. During demineralization native bone growth factor proteins sewn with hydroxyapatite open, which provides background osteoinducing properties of the matrix. As a result the mineral-collagen matrix demonstrates both osteoconductive and osteoinductive properties, which allows us to achieve the highest quality results when replacing bone defects. Non-mineralized matrix has osteoconductive properties and high enough strength. When used as an osteoplastic material, it allows you to form the necessary volume of bone regenerate.

The bone matrix of different fragmentation and different behavior can solve any clinical problem.
World experience in bone tissue processing
We have conducted a detailed analysis of the world's experience in processing allogenic and xenogenic bone tissue. Despite the existence of dozens of methods for manufacturing osteoplastic materials, the number of approaches to processing bone tissue is limited. This is either the use of high temperatures (firing) or the use of "hard" organic solvents to remove fat, or the use of vacuum technologies for physical cleaning of the matrix. There are also combinations of similar techniques. Each approach has advantages, but it also has disadvantages related to the parameters of the final product.
Our raw material processing technology
The technical specification for the development of our method of manufacturing osteoplastic material is based on such characteristics of the biomaterial as the degree of purification, the presence of residual chemical agents, the presence and state of collagen and native growth factors, osteoconductive and osteoinductive properties of the product and thermal reconstruction of hydroxyapatite.

The developed and patented raw material cleaning technology allows removing any type of antigen from the bone material without affecting the biological and mechanical properties of the native bone tissue. Raw materials at the stage of degreasing and cleaning are subjected to unique processing using the latest physical and chemical methods at physiological temperatures. In this case, lipids and intercellular substance are completely removed, and bone microporosity becomes available. This makes it possible after the demineralization stage to release collagen and native protein growth factors, which are the most important supporting proteins and osteoinductive molecules that provide physiological bone regeneration.
Advantage of technology
  • deep cleaning of biotissue from fats, proteins of intercellular substance, as well as from possible viruses
  • formation of an open porous system of the bone matrix
  • the maximum reduction of immunogenicity, enhancement of biocompatibility
  • preserving the natural bimodal porous structure
  • preservation of native protein growth factors
  • possibility of incorporation by recombinant protein factors
  • use of safe reagents that do not affect the toxicity of the implant
  • use of physiological temperatures in the processing of raw materials
The developed raw material processing protocols make it possible to produce biomaterials with different physical, mechanical and behavioral properties. Among the offered products, you can find a product that is necessary for solving individual tasks of any complexity.