Depending on the residual content of the inorganic phase, the bioOST bone matrix is produced with or without collagen. During demineralization bone growth factor proteins sewn with hydroxyapatite are opened. This provides the osteoinducing properties of the matrix. The mineral-collagen matrix demonstrates both osteoconductive and background osteoinductive properties, which allows to achieve the highest quality results. The heat-treated material does not contain collagen. This matrix is a ceramized hydroxyapatite of animal origin (granules of biological apatite and amorphous calcium phosphate in the "natural ratio"). This material has osteoconductive properties and high enough strength. It allows to form the necessary volume of bone regenerate.
World experience in bone tissue processing
We have conducted a detailed analysis of the world's experience in processing allogenic and xenogenic bone tissue. Despite the existence of dozens of methods for manufacturing osteoplastic materials, the number of approaches to processing bone tissue is limited. This is either the use of high temperatures (firing) or the use of "hard" organic solvents to remove fat, or the use of vacuum technologies for physical cleaning of the matrix. There are also combinations of similar techniques. Each approach has advantages, but it also has disadvantages related to the parameters of the final product.
Our raw material processing technology
The technical specification for the development of our method of manufacturing osteoplastic material is based on such characteristics of the biomaterial as the degree of purification, the presence of residual chemical agents, the presence and state of collagen and native growth factors, osteoconductive and osteoinductive properties of the product and thermal reconstruction of hydroxyapatite.
The developed and patented raw material cleaning technology allows removing any type of antigen from the bone material without affecting the biological and mechanical properties of the native bone tissue. Raw materials at the stage of degreasing and cleaning are subjected to unique processing using the latest physical and chemical methods at physiological temperatures. In this case, lipids and intercellular substance are completely removed, and bone microporosity becomes available. This makes it possible after the demineralization stage to release collagen and native protein growth factors, which are the most important supporting proteins and osteoinductive molecules that provide physiological bone regeneration.
Advantage of technology
The developed raw material processing protocols make it possible to produce biomaterials with different physical, mechanical and behavioral properties. Among the offered products, you can find a product that is necessary for solving individual tasks of any complexity.