The raw material for the production of the envelope is a highly purified extracellular collagen matrix of xenogenic origin based on small intestine submucosa. The extracellular collagen matrix (ECM) is a natural biological matrix for cell colonization that acts as a scaffold from collagen and elastin, and surrounds cells in various tissues of animals. ECM regulates cell adhesion, differentiation, proliferation, and migration. ECM has the necessary biocompatible properties and consists of fibrillar proteins (mainly type I collagen and elastin), which provide resilient and durable architectonics. ECM also contains active biological molecules that give the product bioactive properties. Glycoproteins (fibronectin and laminin) promote cell adhesion and proliferation. Glycosaminoglycans (hyaluronic acid and chondroitin sulfate A) reduce inflammation. Proteoglycans (decorin and heparan sulfate) prevent the formation of scar tissue, participate in the fibrillar regulation of collagen, and stimulate angiogenesis.
Resorbable suture from polyglycolic acid
(0.05±0.02)g per 1g of envelope
The patented multi-stage technology of chemical and biological processing of raw materials makes it possible to completely remove cellular elements, while preserving the natural architectonics of fibrillar proteins and the presence of biological molecules. Collagen, together with aminocaproic acid, inhibits fibrinolysis, which initiates hemostasis up to the formation of a fibrin clot during a surgical operation. After the operation, the fibrin clot serves as a matrix for the integration of the recipient’s tissues into the envelope wall.