Extracellular collagen matrix
Pore sizes – from 20 to 30 µm
Thickness – from 0.2 to 0.5 mm
Area – any
(at the request of the customer, a construct of any required size can be made, since the layering technology of raw material is used)
Extracellular collagen matrix is a natural biological scaffold and matrix for cell settlement. The matrix is a framework of collagen and elastin and surrounds cells in almost all tissues. Extracellular collagen matrix regulates cell adhesion, differentiation, proliferation and migration of cells. The biomaterial was obtained by chemical-biological treatment of tissue of xenogenic origin — SIS (small intestine submucose). The patented technology of chemical and biological processing of raw materials allows effectively removing cellular elements and preserving the natural architectonics of fibrillar proteins. Decellularized biomaterial extracellular collagen matrix has excellent biocompatible properties. It consists of fibrillar proteins (mainly type I collagen and elastin) that provide elastic and strong spatial architectonics. Contains in its composition of biologically active molecules, which give the product's bioactive properties. Glycoproteins (fibronectin and laminin) promote cell adhesion, proliferation, and migration. Glycosaminoglycans (hyaluronic acid and chondroitin-sulfate A) reduce inflammation, provide binding and attachment of cells. Proteoglycans (decorin and heparan sulfate) prevent the formation of scar tissue, participate in the fibrillar regulation of collagen and stimulate angiogenesis.
The product is designed for use in laboratories of research institutes in the field of health or biological profile, specializing in cell or tissue engineering and cell culture cultivation.